He was born in Castoria in 1772 and lived the greatest part of his life in Bucharest, where he died in 1847. There he completed basic education with important teachers, such as Gregorios Konstandas and Manasis Eliadis. Then, he travelled to the West and studied medicine and law at Buda and Padova. He returned to Bucharest in 1797 and became a tutor in the house of the Mourouzi leaders. For some time, he followed Mourouzis to Istanbul for business (1806-1812) and there he found the comfort and the appropriate environment to write his poems. In the years to come (1812-1820) at the side of the leader Ioannis Karatzas he will be assigned high offices; he will even reach to the rank of "megalos logothetis" [senior manager] and by order of the leader he drew up a liberal code of laws. In 1819 he joined Filiki Eteria and at the eve of the Revolution he was sent by Ipsilandis to the Ionian Islands to promote the objectives of Filiki Eteria.  When the Revolution started in 1821 he lost all the offices and sought refuge in Sibini in Transylvania.

In 1836, after the creation of the first Greek State, Christopoulos decided to return to Greece, but after a short stay in Nafplio and disappointed from the political and social situation he found in his country he returned to Sibini in Transylvania, where he later died. Christopoulos engaged in multiple activities.

He engaged in different matters: philological, linguistic, literary, philosophical, law and political and other. He is mostly known however as a poet, since he was considered the New Anacreon of Greece. Christopoulos also occupied a significant position in Modern Greek Letters for his language views, since he was a strong supporter of the spoken language to be used in writing.

In 1802 he wrote the drama Achillefs in demotic that was played several times at the theatre and was beyond doubt among the first theatre plays to move Greeks and to excite their patriotism. In 1805, he printed in Vienna the book Grammatiki tisAiolodorikis dialektou, itoi tis omiloumenis ton Ellinon glossis, where he presented his views on language. In this study, he supports that the spoken language of Greeks originates from two ancient dialects, the Aeolian and the Doric dialect.

In 1811, he published the poems collection Lyrika , which established him as a poet. Lyrika is the first authentic lyric voice after the conquest of Crete and following a poetic hypnosis of almost one century and a half and together with the poetry of another Phanariote, that of Ioannis Vilaras, create a new tradition of poetic creation. He divides his poems into love poems and Bacchic poems and they are in the same spirit with European classicism. He writes in demotic, an elegant raw language of high society, and his verse often gives the impression that it seeks to move Phanariote women, who take interest in poetry at the time. He celebrates love and wine and keeps presenting himself hurt from love. The poems of Christopoulos are light and jovial and bring a new breath and a different message. At that time Lyrika were republished several times and had an impact on great poets of the next generation, like Dionysios Solomos.